Endothelial dysfunction and arterial stiffness in pre-eclampsia demonstrated by the EndoPAT method
نویسندگان
چکیده
OBJECTIVES The EndoPAT method has been used as a non-invasive method for assessing endothelial function in several non-pregnant populations. We investigated its possible use in assessing endothelial dysfunction in pre-eclampsia. METHODS Two hundred and fifteen participants were recruited and grouped as pre-eclamptic cases (105) and normotensive controls (110). Endothelial function and arterial stiffness were measured as reactive hyperaemia index and augmentation index, respectively, using the EndoPAT 2000 machine. RESULTS The reactive hyperaemia index was significantly lower in the pre-eclamptic group compared to the normotensive group (p < 0.05). Augmentation index on the other hand was significantly higher in the pre-eclamptic group compared to the normotensive group (p < 0.0001). CONCLUSION The EndoPAT method demonstrates endothelial dysfunction and arterial stiffness in pre-eclampsia.
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